|
KMID : 0894520140180040187
|
|
Development & Reproduction
2014 Volume.18 No. 4 p.187 ~ p.195
|
|
|
Disturbance in Testosterone Production in Leydig Cells by Polycyclic Aromatic Hydrocarbons
|
|
Oh Seung-hoon
|
|
|
Abstract
|
|
|
|
Polycyclic aromatic hydrocarbons (PAHs), which are ubiquitous in the air, are present as volatile and particulate pollutants that result from incomplete combustion. Most PAHs have toxic, mutagenic, and/or carcinogenic properties. Among PAHs, benzo[a]pyrene (B[a]P) and dimethylbenz[a]anthracene (DMBA) are suspected endocrine disruptors. The testis is an important target for PAHs, yet effects on steroidogenesis in Leydig cells are yet to be ascertained. Particularly, disruption of testosterone production by these chemicals can result in serious defects in male reproduction. Exposure to B[a]P reduced serum and intratesticular fluid testosterone levels in rats. Of note, the testosterone level reductions were accompanied by decreased steroidogenic acute regulatory protein (StAR) and 3B-hydroxysteroid dehydrogenase isomerase (3B-HSD) expression in Leydig cells. B[a]P exposure can decrease epididymal sperm quality, possibly by disturbing the testosterone level. StAR may be a key steroidogenic protein that is targeted by B[a]P or other PAHs.
|
|
|
KEYWORD
|
|
|
Polycyclic aromatic hydrocarbons, Endocrine disruptor, Steroidogenesis, Leydig cells
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|